Posted 08/07/18

Karolinska Institutet, Cardiovascular Research Laboratories, Center for Molecular Medicine, Sweden

Six postdoctoral positions (more details)

Six postdoctoral positions funded by the Swedish Heart-Lung Foundation are available in the Cardiovascular Research Laboratories at the Center for Molecular Medicine of Karolinska Institutet.

Application procedure: Please send your application in English marked with reference

number xxx including the following documents:

1. A full CV including date of public defense, title of thesis,

previous academic appointments, academic title, current position

2. A full publication list + 2 references

3. A brief outline of previous and current work, including a motivation

Application sent to:

In the first instance to KI jobb

Karolinska Institutet

Institutionen för medicin, Solna

Helene Utterberg

S3:01 Norrbacka

171 76 Stockholm

email: Helene.utterberg@ki.se

Last date for applications: September 1 2008

 Posted 08/05/21

Imperial College London,  Dept of Bioengineering, UK

Postdoctoral Research Associate

As part of Imperial College London’s recent £9M Research Excellence Award from the British Heat Foundation a 2-year position is available for a candidate who has obtained, or is about to obtain, a PhD involving in vivo cardiovascular studies.  

Closing date: May 30th 2008

Posted 08/05/16

Clinical Sciences at South Bristol, Bristol Heart Institute, UK

Postdoctoral Research Assistant / 1 year
The program supported by an integrated grant from the European Community (RESOLVE) is suited to evaluate the mechanisms by which aging interferes with proper healing and reverts physiologic cicatrisation in a fibro-proliferative process. The impact of aging in stem cell biology and reparative potential is also considered. The program will be strictly integrated with the work of other associated partners in Europe and includes learning activities, such as participation to summer school.

Postdoctoral Research Assistant / 2 years
The program supported by an integrated grant from the NHS is suited to evaluate whether availability and function of stem cells can predict the outcome of revascularization. Furthermore, studies of stem cells biology in vitro are aimed to define whether the patient would benefit from transplantation of those cells into the ischemic myocardium.  

Posted 08/05/07

Division for Experimental Pathology and Immunology - Laboratory for Autoimmunity  Biocenter - Innsbruck Medical University

Post-Doc Position

The project ECIBUG (European Initiative to Fight Chlamydial Infections by Unibased Genomics) is part of the ERA-Net program PathoGenoMics. It involves 9 research groups with excellent international profile from Austria, Finland, Germany and France.
In the laboratory of Georg Wick, Medical University of Innsbruck, Austria, Adam Csordas, MD, was engaged during the first period of this project studying the effect of infection by Chlamydia pneumoniae as an endothelial stressor initiating atherosclerosis as part of his thesis.
In June 2008, Adam will finish his PhD studies and we are looking for a successor with interest in a combination of Endothelial Cell Biology, Immunology and Microbiology.

Applications, including a letter of intent, CVand list of publications should be send to the following address:
Georg Wick, MD, FRCPath.
Professor
Division for Experimental Pathology and Immunology
Laboratory for Autoimmunity Biocenter
Innsbruck Medical University
Peter-Mayr-Straße 4a
6020 Innsbruck
Phone: 0043 (0)512 – 9003 – 70960
FAX: 0043 (0)512 – 9003- 73960
Mail: georg.wick@i-med.ac.at

References:
G. WICK, M. KNOFLACH and Q. XU
Autoimmune and inflammatory mechanisms in atherosclerosis
Annu. Rev. Immunol. 22: 361-403 (2004)
A. CSORDAS, G. WICK and D. BERNHARD
Hydrogen peroxide-mediated necrosis induction in HUVECs is associated with an atypical pattern of
caspase-3 cleavage
Exp. Cell Res. 312: 1753-1764 (2006)
H. PERSCHINKA, B. WELLENZOHN, W. PARSON, R. VAN DER ZEE, J. WILLEIT, S. KIECHL and G. WICK
Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage
display and structural alignment. Atherosclerosis 194: 79 - 87, (2007)

 Posted 08/05/06

Cardiovascular Division, School of Medicine - King’s College, London, United Kingdom

Post-Doctoral Research Fellow
in Stem Cells / Proteomics / Molecular Biology

The above post is supported by the British Heart Foundation and based within the Academic Cardiology Department at the King's College Denmark Hill Campus. The
Vascular Proteomics Group at King’s College is housed in the newly opened James Black Centre. Current research interests focus upon the role of progenitor cells for vascular repair. More detailed information can be found on our home page at

As a minimum requirement, the candidate must have a PhD degree in a science subject.
The salary for the post-doctoral position will be in the range of £29,716 p.a. (approx. 39,000 €) inclusive. Informal enquiries should be made to Dr M. Mayr (contact details below). There is no closing date for applications. To apply, please submit a detailed CV (including details of any research experience), an academic transcript and two academic references to Dr M. Mayr. Please include a covering letter stating why you are interested in this project. If you have had research experience, one of your referees should be your supervisor for this period of research.

Further Information and Contact Details:
Dr Manuel Mayr, Cardiovascular Division, King’s College London, James Black Centre,
125 Coldharbour Lane, London SE5 9NU. Email: manuel.mayr@kcl.ac.uk

Postdoctoral position in: Tumor angiogenesis in zebrafish

The Zebrafish Group invites applications for a postdoctoral candidate with a strong interest and solid background in vascular biology.  Previous experience with the zebrafish model is not required, as we will provide training.

One of the main projects of the lab is the study of tumor angiogenesis using our cancer prone transgenic lines and transplantation techniques. The successful candidate will develop assays to study and manipulate the development of tumor vessels and metastatic migration in vivo.  A range of techniques, including confocal microscopy of live zebrafish and 4D analysis will be used in the project.

Requirements:
MD or PhD in biological subjects. Expertise in vascular biology using both in vivo and in vitro approaches is highly desirable.
We are looking for a highly motivated scientist who wants to broaden her/his expertise in the vascular field with an innovative approach in the zebrafish model. A record of independent research, the ability to work in a team and a strong interest for live imaging are important requisites.

How to apply:
For preliminary inquiries please contact: Marina Mione at marina.mione@ifom-ieo-campus.it,
Web: http://www.ifom-ieo-campus.it/research/mione.php

 Posted 08/04/04

The Future Begins With Us.

With 30.000 students, including 2.700 medical students, and its emphasis on innovative research, RWTH Aachen University is one of the leading universities of technology in Europe. Its teaching and research are characterised by a distinctly international, practice-orientated and interdisciplinary approach.

Full Professor (W2) in Cardiovascular Physiology

Medical Faculty / University Hospital Aachen

We are now seeking qualified applicants for teaching and research in the area of physiology and pathophysiology of the cardiovascular system. The position will be initially available for 5 years with an option for tenure based on a positive interim evaluation.

Recognized expertise to strengthen the cardiovascular focus in the following areas is particularly welcome: the biology of stem and progenitor cells in vascular and myocardial adaption, inflammatory and regenerative cell recruitment, the vasoregulation and microcirculation during ischemia/reperfusion, vascular stress or atherosclerosis. In addition, active engagement in the new medical student’s curriculum of the Medical Faculty and the master programme “Biomedical Engineering” will be expected. Herein, applicants are expected to represent a broad scope of physiology in teaching.

Interdisciplinary cooperation with the other departments of the University Hospital, with the existing research areas and centres of the university such as SFB 542, FOR 809, SFB-TR37, KFO 112, IRTG 1328, the Interdisciplinary Centre for Clinical Research (IZKF BIOMAT.), the research units of the focus areas cardiovascular and inflammation research, including the Cardiovascular Research Institute Maastricht (CARIM), the Institute of Biomedical Technologies (IBMT), the Aachen Competence Centre for Medical Technology (AKM), and other technical disciplines of RWTH Aachen University is required.

An M.D./Ph.D. or Ph.D. is required; additionally, Habilitation (post-doctoral lecturing qualification), an exemplary record of research achievement as an assistant / an associate / a junior professor or university researcher and/or an outstanding career outside academia are highly desirable. Ability in and commitment to teaching are essential. German is not necessary to begin but will beexpected as a teaching language within the first 5 years.

Please send a cover letter stating research aims and a CV and list of publications to: An den Dekan der Medizinischen Fakultät der RWTH Aachen, Universitätsprofessor Dr. med. J. Noth, Pauwelsstraße 30, D-52074 Aachen, Germany. In addition, please fill in the applicant’s questionnaire which you can find on the Internet under www.stellenmarkt.ukaachen.de. The deadline for applications is xxx.

The RWTH Aachen aims to increase the number of women in areas in which they are underrepresented, thus women are strongly encouraged to apply. For further information please see: www.rwth-aachen.de/equality

The RWTH Aachen aims to integrate persons with disabilities, thus such persons are strongly encouraged to apply. For further information please see: www.rwth-aachen.de/disabilities

 Institute for Biomedical research, Department of reproductive and vascular biology, University of Birmingham , UK  Date posted: 14-02-2008

Research Technician (Five Years Post) 

This is a unique opportunity for enthusiastic researcher to work in a multidisciplinary environment of molecular biologists, cell biologists, and clinical scientists and to contribute to research of an active and internationally recognized RAE 6* Research Group occupying well-equipped new laboratories within the Institute of Biomedical Sciences. The position is supported by a MRC programme and strategic project grant and form part of a major initiative to develop and characterize novel therapeutic targets for angiogenesis-based disorders and vascular pathology of pregnancy.  Our laboratory focuses on angiogenesis and VEGF receptor and heme oxygenase signaling (see Circulation 2007, 115:1789-97; Circ Res. 2006, 99:715-22; Circ Res. 2004, 95:884-91; J Clin Invest. 1998, 101:949-55).  You should be highly motivated, well organized individual to support the Reproductive and Vascular Biology research group under the direction of Professor Asif Ahmed. The work involves closely assisting Research Associates and PhD students and you will need to be computer literate, and be able to demonstrate quality team working and communication skills.

You should have either have a BSc or equivalent degree in a biological science related subject and have previous relevant laboratory experience. Experience of histology, murine vascular biology and microsurgery would be desirable. Accuracy, attention to detail, a flexible approach to working hours are desirable.

Reference: M46220

Details can be found HERE

Institute for Biomedical research, Department of reproductive and vascular biology, University of Birmingham , UK Date posted: 14-02-2008

Research Technician (Three Years Post) 

This is a unique opportunity for enthusiastic researcher to work in a multidisciplinary environment of molecular biologists, cell biologists, and clinical scientists and to contribute to research of an active and internationally recognized RAE 6* Research Group occupying well-equipped new laboratories within the Institute of Biomedical Sciences. The position is supported by a MRC programme and strategic project grant and form part of a major initiative to develop and characterize novel therapeutic targets for angiogenesis-based disorders and vascular pathology of pregnancy.  Our laboratory focuses on angiogenesis and VEGF receptor and heme oxygenase signaling (see Circulation 2007, 115:1789-97; Circ Res. 2006, 99:715-22; Circ Res. 2004, 95:884-91; J Clin Invest. 1998, 101:949-55).  You should be highly motivated, well organized individual to support the Reproductive and Vascular Biology research group under the direction of Professor Asif Ahmed.

You should have a BTech (Higher) or BSc in science related subject and have previous relevant laboratory experience.  You should have relevant experience of monitoring clinical trials and proven ability of dealing appropriately with people at all levels.  Working in a biological research laboratory or industry would be advantage. The work involves closely assisting Research Associates and PhD students and you will need to be computer literate, and be able to demonstrate quality team working and communication skills.

Reference: M46219

Details can be found HERE

Institute for Biomedical research, Department of reproductive and vascular biology, University of Birmingham , UK Date posted: 14-02-2008

Research Fellow (Five Years Post)

This is a unique opportunity for enthusiastic researcher to work in a multidisciplinary environment of molecular biologists, cell biologists, and clinical scientists and to contribute to research of an active and internationally recognized RAE 6* Research Group occupying well-equipped new laboratories within the Institute of Biomedical Sciences. The position is supported by a MRC programme and strategic project grant and form part of a major initiative to develop and characterize novel therapeutic targets for angiogenesis-based disorders and vascular pathology of pregnancy.  Our laboratory focuses on angiogenesis and VEGF receptor and heme oxygenase signaling (see Circulation 2007, 115:1789-97; Circ Res. 2006, 99:715-22; Circ Res. 2004, 95:884-91; J Clin Invest. 1998, 101:949-55).  You should be highly motivated, well organized individual to support the Reproductive and Vascular Biology research group under the direction of Professor Asif Ahmed.

You should have a PhD in a biomedical related field with experience of microsurgery would be a distinct advantage..  Additional experience of genetic experimental approaches including in vivo gene therapy, conditional Cre/LoxP gene targeting, inducible gene knockdowns by siRNA would be desirable. . You will need to be computer literate and be able to work in a team with good communication skills.

Reference: M46218

Details can be found HERE

Research Fellow (Five Years Post)

This is a unique opportunity for enthusiastic researcher to work in a multidisciplinary environment of molecular biologists, cell biologists, and clinical scientists and to contribute to research of an active and internationally recognized RAE 6* Research Group occupying well-equipped new laboratories within the Institute of Biomedical Sciences. The position is supported by a MRC programme and strategic project grant and form part of a major initiative to develop and characterize novel therapeutic targets for angiogenesis-based disorders and vascular pathology of pregnancy.  Our laboratory focuses on angiogenesis and VEGF receptor and heme oxygenase signaling (see Circulation 2007, 115:1789-97; Circ Res. 2006, 99:715-22; Circ Res. 2004, 95:884-91; J Clin Invest. 1998, 101:949-55).  You should be highly motivated, well organized individual to support the Reproductive and Vascular Biology research group under the direction of Professor Asif Ahmed.

You should have a PhD in cell or molecular biology, proven excellence in research, and a strong background in molecular biology, including adenoviral or lentiviral vector generation. Additional experience of in vivo models of disease and an interest in cell signaling will also be advantages. You will need to be computer literate with demonstrable ability to write scientific English and be able to work in a team with good communication skills.

Reference: M46217

Details can be found HERE

Institute for Biomedical research, Department of reproductive and vascular biology, University of Birmingham , UK Date posted: 14-02-2008

This is a unique opportunity for enthusiastic researcher to work in a multidisciplinary environment of molecular biologists, cell biologists, and clinical scientists and to contribute to research of an active and internationally recognized RAE 6* Research Group occupying well-equipped new laboratories within the Institute of Biomedical Sciences. The position is supported by a MRC programme and strategic project grant and form part of a major initiative to develop and characterize novel therapeutic targets for angiogenesis-based disorders and vascular pathology of pregnancy.  Our laboratory focuses on angiogenesis and VEGF receptor and heme oxygenase signaling (see Circulation 2007, 115:1789-97; Circ Res. 2006, 99:715-22; Circ Res. 2004, 95:884-91; J Clin Invest. 1998, 101:949-55).  You should be highly motivated, well organized individual to support the Reproductive and Vascular Biology research group under the direction of Professor Asif Ahmed.

You should have either BSc or MBBS or MD and MRCS or equivalent degree. An understanding of scientific knowledge in vascular biology and the ability to perform various biochemical and cellular assays are desirable.  Accuracy, attention to detail, a flexible approach to working hours are essential.  Experience in the collection of tissue and serum samples from patients would be advantageous. You will need to be computer literate, and be able to demonstrate quality team working and communication skills.

Reference: M46216

Details can be found HERE

Division of Immunity & Infection, University of Birmingham , UK Date posted: 14-02-2008

PhD position

Application Deadline 07 March 2008
Endothelial Cell Senescence and impaired endothelial repair mechanisms with age (Professor Asif Ahmed, Professor Michael Frenneaux).
Vascular endothelial growth factor (VEGF) is critical for normal vascular development, angiogenesis and revascularization after endothelial injury (17). VEGF is implicated in angiogenesis, which activates the angiogenic signalling cascade through Akt and endothelial nitric oxide synthase (eNOS)-related pathway (18). Repair of endothelial injury is known to be impaired with age and this project will test the hypothesis that a primary factor is endothelial senescence induced down-regulation of the endothelial VEGF angiogenic signaling cascade, which affects eNOS activity and angiogenesis.

To determine if aging endothelial cells retain their structure-function relationship of the VEGF receptors and their signaling intermediaries in nitric oxide (NO) release and capillary morphogenesis. This study will: (i) define precisely the tyrosine residues of VEGFR-1 and VEGFR-2 in the activation of eNOS and neovascularisation in low (12) passaged cells; (ii) identify the proteins associated with key tyrosine residues that are required for eNOS activation and/or capillary morphogenesis and their downstream effectors; (iii) delineate the downstream signaling pathways utilized by VEGFR-1 and VEGFR-2 to stimulate NO release and neovascularisation.

To characterize the tyrosine residues in VEGFR-1 and/or VEGFR-2 responsible for eNOS activation and capillary morphogenesis, a series of chimeric receptors carrying a tyrosine-to-phenylalanine mutation will also be used.

These constructs will be transduced into human umbilical vein endothelial cells (HUVEC). To identify signaling intermediates downstream of VEGFR-1 or VEGFR-2, the project will adopt two complementary approaches (i) gene knockdown using short hairpin RNAs (shRNA), (ii) the over-expression of wild-type and dominant-negative (dn-) signaling proteins including PLC

Funding Notes

The first year is a foundation year offering training in several disciplines and rotation through three research groups chosen by the student. At the end of the first year the student selects a research topic for the final 3 years. To apply students must be citizens of the UK/EU and hold or expect to gain a First class or 2i honours degree, or equivalent, in a life science subject. To apply send a CV and a short statement of interest to the Programme Director, Professor Lord Email: J.M.Lord@bham.ac.uk. Shortlisted candidates will be asked to attend for interview w/c March 18th.

1. Ahmad S, Hewett PW, Wang P, Al-Ani B, Cudmore M et al. (2006) Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res 99(7): 715-722.

2. Ferrara N (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25(4): 581-611.

Details can be found HERE

Post-doctoral position in Molecular mechanisms implicated in the development of metabolic diseases

Our aim is to unravel the molecular mechanisms implicated in the development of metabolic diseases predisposing to atherosclerosis, such as insulin resistance, dyslipidemia and obesity.

Localisation: Unité INSERM 545, Institut Pasteur de Lille (http://www.pasteur-lille.fr)

Details can be found HERE

Date posted : 29-12-2006

A 3-year Post-doc position is open at the Bristol Heart Institute (Dr. Emanueli laboratory) to work on the cardiovascular actions of neurotrophins. This project will particularly target the neurotrophin P75 receptor.

Download details HERE

University of Bristol

Post-doc position: role of human tissue kallikrein in angiogenesis and vasculogenesis - summer 2006

Recruitment period from now to June 30

One three year postdoc position is available at the Division of Experimental Cardiovascular Medicine, University of Bristol sponsored by the British Heart Foundation for studies on "The role of human tissue kallikrein in angiogenesis and vasculogenesis: insights into the mechanisms". Candidates should have expertise in vascular biology, molecular biology and possibly previous experience with animal models. The work includes the use of FACS analysis of circulating and bone marrow stem cells, gene expression, immunohistochemistry

INSERM U698

Inserm Green Post, Postdoctoral position - July 18 2006

Within the group of Jean-Baptiste MICHEL (cardiovascular remodelling), located at the Xavier Bichat Hospital, 75018 Paris, France, the position of a Post Doctoral fellow available for 1 or 2 years , from September 2006. The research activities of the working group concentrate on atherothrombosis pathology in human, the involvement of intraplaque haemorrhages in the complication of atherosclerosis, the pathophysiology of abdominal aortic aneurysms. The working group participates in several coordinated programmes of the Leducq Fundation transatlantic network of excellence on atherothrombosis.

Leiden University

Post-Doctoral Fellow (m/f) (38 hr p/w) - 27/07/2007

to take a leading role in a research program on the dynamics of leukocyte subsets in the advanced, vulnerable plaque. The Post-Doc will coordinate the program and will operate in close collaboration with two PhD students who already have started on the program. More specifically the candidate will study to what extent cell death related processes (e.g. apoptotic cell handling and autophagy) in the advanced atherosclerotic plaque will affect disease progression. Hereto the Post-Doc will utilize a range of state-of-the-art techniques, including viral shRNA/gene transfer (Bot et al. Blood, 2005; Zernecke et al. Circ.Res., 2005), an in-house vulnerable plaque model (Von der Thuesen et al. Circulation, 2002; Bot et al. Circ Res., 2003) and bone marrow transplantation (Van Eck et al. Proc.Natl.Acad.Sci, 2002). Moreover, the Post-Doc will complement the studies with in vitro assays and histological and gene profiling analyses (real-time PCR and gene chip analysis).

Post-Doctoral Fellow (m/f) (38 hr p/w) - 27/07/2007 to take a leading role in a research program on the dynamics of leukocyte subsets in the advanced, vulnerable plaque. The Post-Doc will coordinate the program and will operate in close collaboration with two PhD students who already have started on the program. More specifically the candidate will study to what extent cell death related processes (e.g. apoptotic cell handling and autophagy) in the advanced atherosclerotic plaque will affect disease progression. Hereto the Post-Doc will utilize a range of state-of-the-art techniques, including viral shRNA/gene transfer (Bot et al. Blood, 2005; Zernecke et al. Circ.Res., 2005), an in-house vulnerable plaque model (Von der Thuesen et al. Circulation, 2002; Bot et al. Circ Res., 2003) and bone marrow transplantation (Van Eck et al. Proc.Natl.Acad.Sci, 2002). Moreover, the Post-Doc will complement the studies with in vitro assays and histological and gene profiling analyses (real-time PCR and gene chip analysis).

The post is an integral part of a broader research program on plaque vulnerability and will benefit from the available infrastructure and stimulating scientific environment. Furthermore it is embedded in a network of collaborations with leading groups within the Netherlands and in Europe (e.g. the European Vascular Genomics Network of Excellence).

Professorial Appointments - 04 Sept. 2006

We seek to make two appointments at senior Professorial level in our expanding department to maintain our high academic standards, to reinforce our international research profile, and to play a role in the department%u2019s management. The appointees will have a very strong international standing in their area of research.

Following the imminent retirement of two members of staff with particular interests in Biomechanics, we will especially welcome applications in the area of biofluids or soft tissue mechanics. However, the Department is keen to receive high quality applications in the broad area of Biological and Medical Engineering. The Department of Bioengineering, a part of the Faculty of Engineering, applies engineering and physical science to a wide range of problems in medicine and biology. It has a long and prestigious history spanning five decades and was awarded a 5* rating in the 2001 Research Assessment Exercise. The Department is currently has 17 academic staff from a variety of disciplines and backgrounds and is undergoing a phase of expansion to complement its current strengths.

The Department views bioengineering as an essentially interdisciplinary venture and there are ample opportunities for collaboration with other groups and faculties within Imperial College, which includes the largest medical school in the UK. Current research interests in the department are very diversified and can be explored via our website at http://www3.imperial.ac.uk/bioengineering.

The Department has active teaching programmes at PhD, MSc and undergraduate levels. Teaching experience in a relevant field is consequently highly desirable.

The salaries for these positions are negotiable. Other associated benefits will be the normal package for Imperial College academic staff.